The extracellular interface of neuron-glia interactions
The brain extracellular matrix plays a key role in chronic pain. We examine the extracellular regulation of neuron-glia crosstalk, in vivo and in vitro, using various biophysical (AFM, SEM) and biochemical (IHC, single-cell western blotting) tools.
Neurocognitive changes in chronic pain conditions
Pain is more than nociception. Experiencing chronic pain is often associated with alterations in mood and memory function. We study these changes in mice using complex behavioral paradigms.